The Sword Difference
We can analyze your nonclinical or clinical samples for specific biomarkers using the existing MSD singleplex or multiplex panels.
Alternatively, using the MSD platform and reagents, we can develop customized assays specific to your projects unique needs.
How Our Team Can Help
Biomarker Analysis
- Precise quantitation of disease biomarkers using MSD singleplexed or multiplexed biomarker panels (S-PLEX, V-PLEX, U-PLEX, R-PLEX, and T-PLEX)
- Proprietary singleplexed or multiplexed immunoassay development
- High performance (high sensitivity, accuracy, precision) immunoassay development
- Fit-for-purpose method performance qualification
- Intracellular signaling (phosphorylation) immunoassays
- Competitive immunoassays
- Protein-protein interaction assays
- Biomarker analysis can be performed under Non-GLP or GLP
Top Benefits of MSD Assays:
Sword bio is capable of running all MSD singleplex and multiplex kits and has qualified the below:
- High Sensitivity
- Broad Dynamic Range
- Robust & Rugged
- High Throughput
- Adaptability to Automation
- Small Sample Volumes
- Multiplexing
Below is an example of some of the qualified biomarkers we currently run, please reach out for a full list:
| V-PLEX Human Biomarker 40-Plex Kit | |||
|---|---|---|---|
| IFN-γ | GM-CSF | IL-8(HA) | VEGF-C |
| IL-1β | IL-5 | MCP-1 | VEGF-D |
| IL-2 | IL-16 | MCP-4 | Tie-2 |
| IL-4 | IL-7 | Eotaxin | VEGFR-1/Flt-1 |
| IL-6 | IL-12/IL-23p40 | IP-10 | PIGF |
| IL-8 | IL-1α | MDC | FGF (basic) |
| IL-10 | VEGF-A | Eotaxin-3 | SAA |
| IL-12p70 | IL-17A | TARC | CRP |
| IL-13 | IL-15 | MIP-1α | VCAM-1 |
| TNF-α | TNF-β | MIP-1β | ICAM-1 |
| 40-plex | |||
MSD Biomarker Assay Services
At Sword Bio, our MSD assay services are designed to meet the most demanding translational and regulatory bioanalytical challenges. We leverage MSD's electrochemiluminescence technology for high sensitivity, broad dynamic range, and robust multiplex capability—all essential for precise biomarker quantitation in complex drug development pipelines.
Enhanced Service Offerings
Custom MSD Panel Design
Tailored panel creation based on target analyte profiles, dynamic range requirements, and sample throughput needs.
Platform Optimization
Strategic selection between S‑PLEX, V‑PLEX, U‑PLEX, R‑PLEX, or T‑PLEX formats depending on sensitivity, multiplexing, and sample volume constraints.
Multiplex Validation Strategy
Full analytical validation (including precision, accuracy, cross-reactivity, and matrix interference studies) conducted across all targets simultaneously.
Singleplex-to-Multiplex Transition
Scalable workflow development to move from broad exploration (multiplex) toward targeted validation (singleplex) to satisfy pivotal study requirements.
Matrix Flexibility
Validation across diverse matrices—including plasma, serum, CSF, urine, and tissue homogenates—with parallelism and spike-recovery testing.
Non‑GLP and GLP-compliant
Flexible delivery model—from rapid exploratory assays in a non‑GLP setting to fully validated GLP-compliant assays, complete with audit-ready documentation.
Why Choose Sword Bio
- Regulatory-Ready Validation: We conduct GLP-compliant MSD assay validation aligned with FDA, EMA, and ICH standards, delivering submission-ready documentation.
- Elevated Translational Insight: MSD assay design is strategically aligned with PK/PD modeling, MOA, and clinical endpoints to support translational decision-making.
- Unmatched Multiplex Proficiency: Deep experience in MSD multiplexing, managing inter-analyte interference and matrix effects, with streamlined deconvolution to singleplex formats.
- Comprehensive Quality Controls: SOP-driven operations, audit-ready quality systems, and robust data integrity measures ensure assay reliability and reproducibility.
- Scientific Leadership: Backed by decades of MSD and biomarker assay expertise, our team ensures technical rigor and strategic relevance in every project.