High Sensitivity ELISA Alternative to MSD

Our Sword Bio Sword Swift reagents for HRP ELISA have enabled the development of high-sensitivity validation assays that match the sensitivity of MSD systems. These enhanced ELISA systems can be validated according to the ICH Q2(R1) guidance for specificity, linearity, Truness, Precision, the limit of detection (LOD), the limit of quantification (LOQ), range, and robustness. The Sword Swift™ detection reagents and signal amplification techniques facilitate achieving lower detection limits and greater precision.

High Sensitivity Biomarker and Protein ELISA Alternative to MSD

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The Sword Swift™ ELISA reagents provide sensitivity comparable to a validated MSD assay. Additionally, they are more cost-effective than validated MSD assays, making them an attractive option for enhancing sensitivity in existing ELISA assays.

How Our Team Can Help

Our LBA team can participate in analyzing your ELISA system to increase the sensitivity, accuracy, and precision of therapeutics, biomarkers, and proteins with quality and efficacy. We can significantly enhance your ELISA assay by leveraging the Sword Swift advanced analytical techniques with standard fluorescent plate readers. Here are some key ways our LBA team can make a difference

  • Enhanced Sensitivity, Accuracy, and Specificity
  • Validate the Sword Swift ELISA and run Toxicology and Clinical Samples
  • Provide you with the Sword Swift Reagents
  • Can Develop and Transfer Sword Swift Assay Back to the Client
  • Work with Your Scientific Team to Optimize Existing Biomarkers, Proteins, and Therapeutics ELISA
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The Sword Difference

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Sword Bio has extensive experience in the development process that involves selecting the appropriate ELISA format—such as direct, indirect, or sandwich ELISA. The Sword Swift detection reagents have been used for multiple biomarkers and therapeutics and were vital to achieving robust, accurate, and increased sensitivity results. Sword Bio has also validated multiple Sword Swift assays for clinical samples. Since this advanced ELISA system can use standard fluorescent plate readers and HRP enzyme-linked detection, it has become a valuable alternative to the MSD system. These advancements have made the Sword Swift ELISA system indispensable in producing high sensitivity for therapeutic antibodies, proteins, and biomarkers

References

Donald L. Very, Jr., Tori Klenk, Derek Gille, Janelle Gibson, Rob Donoho, and Brian Burmeister. “Next Generation Immunoassays: Use of the Sword Swift™ Method Development Process and Proprietary Detection Reagents in the Rapid Development of a Human TGF-β1 Immunoassay with Superior Accuracy, Precision, and Sensitivity” WP 22-175, June 2022

Donald L. Very, Jr., Tori Klenk, Derek Gille, Janelle Gibson, Rob Donoho, and Brian Burmeister. “Robust and Stable Assay Signal Generation By Sword Swift™ Assay Detection Reagents Leads to Superior Precision, Accuracy, and Sensitivity In Analyte Quantitation” WP 22-208, July 2022

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