IL-23 is secreted by both macrophages and dendritic cells as a host defense and wound healing response. It has been implicated in several inflammatory and autoimmune diseases, including psoriasis, psoriatic arthritis, Crohn’s Disease and ankylosing spondylitis. Genome-wide association studies (GWAS) have also linked IL-23 to ulcerative colitis, inflammatory bowel disease (IBD) and graft-versus-host disease.2
This Sword Assay has been optimized for use with the R&D Systems Quantikine ELISA for Human IL-23 (Catalog No. D2300B).
Table 2. IL-23 levels were quantified in human plasma EDTA from healthy donors using the R&D Systems Human IL-23 Quantikine ELISA (D2300B) with Sword Assay for Human IL-23. Donor samples were tested in duplicate in three separate runs.
Table 4. Human IL-23 Reference Standard was spiked into pooled human plasma EDTA from healthy donors. Human IL-23 levels were quantified using the R&D Systems Human Il-23 Quantikine ELISA (D2300b) with Sword Assay for Human IL-23.
Table 5. Human IL-23 was quantified in human serum from twelve healthy donors using the R&D Systems Human IL-23. Measured human IL-23 levels varied from not detectable (ND) to 77.93 pg/ml. Mean and median IL-23 levels were 8.70 pg/ml and 1.09 pg/ml, respectively.
Table 6. Human IL-23 was quantified in human plasma EDTA from twelve healthy donors using the R&D Systems Human IL-23 Quantikine ELISA (D2300B) with Sword Assay for Human IL-23. Measured human Il-23 levels varied from not detectable (ND) to 5.56 pg/ml. Mean and median human IL-23 levels were 1.03 pg.ml and 0.80 pg/ml, respectively.
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